Addressing Acne From the Inside Out

Biology

3 Min Read

By Nutrafol Team2024-05-30

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What is acne?

Acne is a common skin concern that occurs when hair follicles under the skin become clogged. As sebum and dead skin cells build up within the pores, it allows bacteria to grow and can eventually lead to lesions on the skin, known as pimples.¹

There are a variety of factors that trigger acne—many of which lie beneath the skin. Through our research, we’ve uncovered 6 key root causes that can lead to mild to moderate acne in women specifically: stress, normal hormonal fluctuations, the gut and skin microbiomes, immune function, metabolism, and lifestyle. Multi-targeting these underlying causes is an effective way to address acne at the source, instead of relying on surface-level solutions.²

How can acne affect women differently throughout life?

Many young women experience mild to moderate acne at some point in life—most often during adolescence, as it’s typically linked to hormonal changes around the menstrual cycle. While teenage acne clears for some, others continue to deal with breakouts and skin concerns well into adulthood. Then, there are women who develop acne for the first time in their 20s, 30s, or 40s.³

Despite being an incredibly common issue that women face, dealing with acne can take a major toll mentally, physically, and emotionally. We’ve heard from our dermatologist partners and our team and were determined to create a product that would help alleviate this burden for those who have been struggling with acne for years.

What is Clear Skin Nutraceutical and how does it address acne?

Products that target acne on the surface of the skin may offer a temporary break from breakouts, but they’re not getting to the root of why they’re happening in the first place. We decided it was time for a new approach—one that addressed the key underlying factors within the body that lead to mild to moderate acne (without a prescription or any unwanted impacts).

So we created Clear Skin Nutraceutical, a 100% drug-free, vegan supplement designed specifically for women 18+ with mild to moderate acne. This groundbreaking formula takes a whole-body approach by targeting key root causes of acne—such as stress, hormones, and the gut microbiome—from within to deliver clearer, smoother skin.

Key ingredients for clearer skin.

Clear Skin Nutraceutical is physician-formulated with standardized vitamins, minerals, and natural ingredients that support skin health from within.

Holy Basil: An adaptogenic herb clinically shown to balance the body’s response to daily stress as a root cause of acne.^20,21
Maca: An adaptogenic root formulated to accompany Selenium, which targets normal hormonal fluctuations.^18,19
Berberine: Balances metabolism as a root cause of acne.^7,8
Curcumin: Extracted from Turmeric to support a healthy immune response.^22,23
Sicilian Orange: Sourced from blood orange juice and clinically shown to support a healthy response to oxidative stress.^11,12
Postbiotics: Improve diversity of gut flora for healthy digestion and increase hydration in the skin.^24-26

When to expect results.

In a clinical study, users saw results in as little as 4 weeks on Clear Skin Nutraceutical.

1-4 weeks: Vitamins, minerals, probiotics, and natural botanicals begin to reduce stress levels, support a healthy gut microbiome and metabolism, and target free radicals to reduce new breakouts, balance oil production, and promote skin cell turnover.^2,4,14
5-8 weeks: Ingredients begin to target normal hormonal fluctuations that cause monthly breakouts to improve skin clarity, promote a smoother texture, increase hydration, reduce redness—all for healthier-looking skin.^2,18,19
9-12 weeks and beyond: Ingredients continue to promote a healthy immune response and support healthy digestion to decrease acne overall for visibly clearer skin and improved post-acne dark spots.^2,4-6,15-17

Featured Products

Skin

For non-cystic acne. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References: 1. National Institute of Health. NIAMS. June 2023. Accessed April 11, 2024. https://www.niams.nih.gov/health-topics/acne 2. Burgess et al. J Drugs Dermatol. 2024./Nutrafol. Data on file. 2023. 3. Bagatin, E., et al. An Bras Dermatol. 2019. 4. Cuentas, A. J Prob Health. 2017. 5. Colom, J. Beneficial Microbes. 2023. 6. Feedman, K.Int. J. Mol. Sci. 2021. 7. Petrangolini, G. Evidence-based Complementary and Alternative Medicine. 2021. 8. Rondanelli, M. Nutrients. 2021. 9. Lopresti, A. Front. Nutr. 2022. 10. Sampath, S. Indian J Physiol Pharmacol. 2015. 11. Nobile, V. Nutrients. 2022. 12. Puglia, C. Journal of Cosmetic Dermatology. 2014. 13. Health Canada. Lycopene Monograph. 2009. 14. Chen, J. J Med Food. 2013. 15. Uchiyama, T. Journal of Health Science. 2008. 16. EFSA. EFSA Journal. 2015. 17. Konijeti, G. J Clin Endocrinol Metab. 2016 18. Razavi, M. Horm Metab Res. 2015. 19. Ross, A. Bloomberg School of Public Health. 2012. 20. Lopresti, A. Front. Nutr. 2022. 21. Sampath, S. Indian J Physiol Pharmacol. 2015. 22. Gopi, S. Phtother. Res. 2017. 23. Sahebkhar, A. Pharmacological Research. 2016. 24. Nakai, Journal of Immunotoxicology. 2021. 25. Tanaka, European Journal of Nutrition. 2019. 26. Yoshitake, Front. Med. 2022.